Biopolym. Cell. 2015; 31(5):323-337.
Огляди
Особливості молекулярних механізмів передчасного клітинного старіння, які залежать від стрес-фактору, що індукує старіння
1Петрова Надєжда В., 1Величко Артем К., 1Петрова Наталія В., 1, 2Разін Сергій В., 1Кантидзе Омар Л.
- Інститут біології гена РАН
вул. Вавілова 34/5, Москва, Російська Федерація, 119334 - Московський державний університет імені М. В. Ломоносова
Ленінські гори, 1/12, Москва, Російська Федерація, 119991
Abstract
Клітинне старіння є відповіддю клітини на стрес у вигляді перманентного арешту проліферації, супроводжуваного комплексом фенотипічних змін. Найбільш важливими ознаками клітинного старіння є відсутність синтезу ДНК, збільшення активності асоційованої зі старінням β-галактозидази і збільшення експресії інгібіторів циклин-залежних кіназ. Ці універсальні маркери клітинного старіння характерні також і для інших типів арешту проліферації клітин. Поряд з універсальними маркерами клітинне старіння має додаткові характеристики, які більшою мірою залежать від фактора, що індукує старіння та / або типу клітин. У цьому огляді ми розглянемо основні характеристики і механізми, індукції клітинного старіння, приділивши особливу уваги залежних від стрес-фактора відмінностям активуються при клітинному старінні сигнальних каскадів.
Keywords: клітинне старіння, теломери, пошкодження ДНК, опромінення, активні форми кисню, онкогени
Повний текст: (PDF, англійською)
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