Biopolym. Cell. 2011; 27(3):181-192.
Огляди
Інгібітори лізосомних цистеїнових протеїназ
1Чорна В. І., 2Лянна О. Л.
- Дніпропетровський державний аграрний університет
вул. Ворошилова, 25, Дніпропетровськ, Україна, 49600 - Дніпропетровська державна медична академія
вул. Дзержинського, 9, Дніпропетровськ, Україна, 49044
Abstract
Огляд присвячено інгібіторам цистеїнових протеїназ, відомих своїм важливим значенням для багатьох біохімічних процесів, які відбуваються в живому організмі. Вони також беруть участь у виникненні та розвитку значної кількості захворювань, спричинених, серед іншого, анормальним білковим кругообігом. Одним із головних регуляторів активності зазначених протеїназ є їхні специфічні інгібітори – цистатіни. Мета даного огляду полягає у висвітленні сучасних уявлень щодо ендогенних інгібіторів лізосомних цистеїнових протеїназ та їхніх синтетичних аналогів.
Keywords: цистатини, стефіни, кініногени, цистеїнові катепсини, синтетичні інгібітори
Повний текст: (PDF, українською)
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